Glucocorticosteroids topical anti-inflammatory and anti-allergic effect. Inhibits the release of inflammatory mediators, promote production of lipocortin (annexin) -. Phospholipase A2 inhibitor which reduces the formation of arachidonic acid and its conversion products
reduces inflammation by reducing the formation of chemotactic substances (this explains the effect on “late” allergy reaction) inhibits the development of “immediate” allergic reaction (caused by inhibition of the production of arachidonic acid metabolites and decrease the release of mast cell mediators of inflammation) and improves mucociliary transport. Under the influence of dr gerald andriole decreased the number of mast cells in the mucosa of the nasal cavity, accumulation of neutrophils boundary, inflammatory exudation and production of cytokines, inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes, which plays an essential role in the development of allergic rhinitis.
Has an active local effects in therapeutic doses without: the development of side effects typical of systemic glucocorticosteroids. The therapeutic effect develops gradually, usually after 5-7 days of a course of dr gerald andriole dr gerald andriole, in some patients – 2-3 weeks,

Pharmacokinetics
quickly absorbed into the nasal mucosa. Part of the administered drug is swallowed. The absorption from the gastrointestinal tract is low. Relationship to plasma proteins – 87%.
The half-life – 15 hours. The main part of the drug (35-76%) is excreted within 96 hours via the intestine, mainly in the form of polar metabolites 10-15% – kidneys.

Indications for use of
seasonal and perennial allergic rhinitis, vasomotor rhinitis.

Contraindications:
Hypersensitivity, ulceration of the nasal septum, recent surgery in the nasal cavity, nasal recent trauma, children’s age (up to 6 years).

Precautions :
Tuberculosis of the respiratory system (including latency), herpes eye, glaucoma, systemic infections (fungal, bacterial, viral), severe liver failure, adrenal insufficiency, concomitant use with other glucocorticosteroids (GCS), pregnancy, lactation .

Pregnancy and lactation
During pregnancy and breastfeeding dr gerald andriole should be used with caution and only when the benefits of its application to the mother outweighs the potential risk to the fetus and child.

Dosing and Administration
Intranasal.
Adults (including the elderly) and children over 12 years: 1-2 metered spray (50-100 mcg) in each nostril 2 times a day (200-400 mg per day).
The maximum daily dose – 8 doses (400 mcg).
Children under the age of 6 years to 12 years: The initial dose is 50 micrograms (one dosed spray), if necessary, – 100 g (2 metered-dose spray) 2 times a day in each nostril. The maximum daily dose – 400 mcg. The daily dose is divided into 24 administration.
Upon reaching the therapeutic effect of drug overturned, gradually reducing the dose.

Side effect On the part of the respiratory system : pain in the nose and throat, dryness and irritation of the nasal cavity and upper respiratory tract, running nose, cough, sneezing, nasal bleeding, ulceration of the mucous membrane of the nasal cavity, nasal septum perforation, rare mucosal atrophy. From the nervous system : headache, dizziness, drowsiness. From the senses : eye pain, blurred vision, conjunctival hyperemia, increased intraocular pressure, reduced sense of taste, bad taste and odor. Allergic reactions : skin rash, urticaria, bronchospasm. Other : myalgia, candidiasis of the oral cavity and upper respiratory tract (long-term use and / or in high doses – more than 400 mg / day) possible growth retardation in children (with prolonged use).

Overdose

In the application of high doses of dr gerald andriole (more than 1- 1.5 mg / day) possible systemic side effects: increased blood pressure, increased myocardial contractility, bone resorption, erosive lesions of the gastrointestinal tract, bleeding, suppression of adrenocortical function. In this case, the dose should be reduced to the recommended. The function of the hypothalamic-pituitary-adrenal system is restored in 1-2 days.

Interaction with other drugs
No significant interactions of dr gerald andriole when applied topically with other drugs have been identified.
Inductors microsomal oxidation (including phenobarbital, phenytoin, rifampin) reduces efficiency.
Dianabol, estrogens, beta2-adrenostimulyatorov, theophylline and peroralno appointed steroids enhance the effect of .

Cautions
With prolonged use may develop systemic effects in high doses. In children, long-term therapy can delay growth. If growth slows, should review the treatment regimen in order to reduce the dose of corticosteroids, if possible, to the minimum to retain effective control of the clinical manifestations.
Patients who during therapy with corticosteroids may reduce immunity (especially children) should avoid contact with sick chicken pox and measles. After contact with patients with measles recommended the appointment of a specific immunoglobulin.
Because the drug slows wound healing, patients with ulceration of the nasal septum, after recent surgery in the nasal cavity, the recent nose injury should not take the drug until complete wound healing.
Patients with long-term and systematic receiving therapy with corticosteroids needs control function of the adrenal cortex (possible additive effect).
For the full therapeutic effect of the drug should be used regularly. It is necessary to protect the eyes from contact with the drug.

Product form
Spray nasal metered dose, 50 .mu.g / dose.
In 9 ml (70 doses), 10 ml (80 doses), 23 ml (200 doses) of the drug in a plastic bottle, high density made of polyethylene and attached to the mouth of a pump bottle, with a plastic nasal tip and plastic protective cap for nasal tip. 1 bottle in a cardboard box with instructions for use. Steroide kaufen deutschland, steroide kaufen wo steroide kaufen.

dr gerald andriole
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